Abstract | OBJECTIVE: To evaluate the clinical efficacy and tolerability of pioglitazone monotherapy or in combination with sulfonylurea therapy in the treatment of chinese patients with type 2 diabetes. METHODS: This 12-week study involved 117 patients with type 2 diabetes whose blood glucose was uncontrolled on a stable regimen of diet or oral sulfonylureas for at least 3 months (fasting blood glucose (FBG) 7.8-15.0 mmol/L; postprandial blood glucose (PBG) >11.1 mmol/L)). The patients received once daily pioglitazone 30 mg plus diet (Group PIO-mono) or sulfonylurea (Group PIO-SU). The fasting and postprandial plasma glucose, serum insulin, C-peptid, lipid profile, free fatty acids (FFAs) levels were measured at baseline and every 4 weeks after treatment. Results All patients showed significant improvement in glycemic control over baseline. There were 1.64%, 2.1 mmol/L, 5.2 mmol/L decrease from baseline HbA1c, FBG and PBG levels in the Group PIO-mono and 1.06%, 2.3 mmol/L, 5.4 mmol/L decrease in the Group PIO-SU after 12 weeks treatment, respectivley. Both groups experienced slight decreases in C-peptide and insulin concentrations during 12 weeks period. Both groups showed mean percent decreases in triglyceride and FFA levels(21.8% and 20.7% for PIO-mono, 22.2% and 14.5 for PIO-SU) and increases in HDL-C (21.4% for PIO-mono and 30.8% for PIO-SU), compared with baseline. pioglitazone was well tolerated. CONCLUSION: In patients with type 2 diabetes, pioglitazone monotherapy or in combination with sulfonylurea therapy significantly improves HbA1c, FBG and PBG levels and reserves the beta-cell function with beneficial effects on serum triglyceride and HDL-C levels.
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Authors | Yerong Yu, Yanbing Li, Jiyuan Fan, Yan'gang Wang, Honglin Yu, Chun Wang, Zhihong Liao, Hua Gao, Wenjuan Zhao |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 34
Issue 1
Pg. 117-20
(Jan 2003)
ISSN: 1672-173X [Print] China |
PMID | 15600200
(Publication Type: Journal Article)
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Chemical References |
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Sulfonylurea Compounds
- Thiazolidinediones
- Pioglitazone
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Topics |
- Adult
- Aged
- Diabetes Mellitus, Type 2
(drug therapy)
- Drug Therapy, Combination
- Female
- Glycated Hemoglobin
(metabolism)
- Glycemic Index
(drug effects)
- Humans
- Hypoglycemic Agents
(administration & dosage)
- Insulin Resistance
- Male
- Middle Aged
- Pioglitazone
- Sulfonylurea Compounds
(administration & dosage)
- Thiazolidinediones
(administration & dosage)
- Treatment Outcome
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