Abstract | BACKGROUND: Although the origin of cardiac myxomas is still controversial, the 2 main hypotheses are that the tumor cells originate either from multipotential mesenchymal cells or from endocardial neural tissue. METHODS AND RESULTS: CONCLUSIONS: The similarity of the cytokine production pattern between cardiac myxoma cells and endothelial cells supports the hypothesis that the tumor cells originate from mesenchymal cells capable of endothelial differentiation. Overproduction of CXC chemokines may explain, in part, the malignant potential of histologically benign myxomas.
|
Authors | Hironosuke Sakamoto, Tetsuo Sakamaki, Hiroyuki Sumino, Yoshie Sawada, Hiroko Sato, Mahito Sato, Kin'ichi Fujita, Tsugiyasu Kanda, Jun'ichi Tamura, Masahiko Kurabayashi |
Journal | Circulation journal : official journal of the Japanese Circulation Society
(Circ J)
Vol. 68
Issue 12
Pg. 1230-2
(Dec 2004)
ISSN: 1346-9843 [Print] Japan |
PMID | 15564714
(Publication Type: Case Reports, Comparative Study, Journal Article)
|
Chemical References |
- Culture Media
- Endothelin-1
|
Topics |
- Adult
- Cell Line, Tumor
- Cells, Cultured
- Culture Media
(chemistry)
- Endothelial Cells
(metabolism)
- Endothelin-1
(biosynthesis)
- Enzyme-Linked Immunosorbent Assay
- Female
- Heart Neoplasms
(etiology, metabolism, pathology)
- Humans
- Middle Aged
- Myxoma
(etiology, metabolism, pathology)
- Umbilical Veins
(cytology, metabolism)
|