Resolution of alcoholic neuropathy following liver transplantation.

Abstract

Between 10 and 20% of adult liver transplants are performed for end-stage alcoholic liver disease. Severe extrahepatic end-organ damage from alcoholism (cardiomyopathy, pancreatitis, central nervous system injury, and neuropathy) is widely regarded as an absolute contraindication to liver transplantation, despite a lack of data on the effect of transplantation on these complications. We describe such a patient who presented with decompensated alcoholic liver disease and moderately severe peripheral neuropathy. Both his liver failure and neuropathy progressed despite 9 months abstinence and intensive nutritional support. By 12 months post-transplant, however, this patient had regained almost normal muscle strength, with associated recovery in sensory and motor conduction velocities. Direct alcohol toxicity, nutritional and vitamin deficiencies, and liver failure were all likely etiologic factors in this patient's neuropathy. In conclusion, this case suggests that peripheral neuropathy in a patient with alcoholic cirrhosis may resolve following liver transplantation and should not constitute a contraindication to transplantation, even when it is disabling.

• Authors: Edward Gane, Rachael Bergman, David Hutchinson
• Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (Liver Transpl) Vol. 10 Issue 12 Pg. 1545-8 (Dec 2004) ISSN: 1527-6465 [Print] United States
• PMID: 15558589 (Publication Type: Case Reports, Journal Article)

Topics

• Alcoholic Neuropathy (physiopathology)
• Humans
• Liver Cirrhosis, Alcoholic (surgery)
• Liver Transplantation
• Male
• Middle Aged
• Motor Neurons
• Muscle, Skeletal (physiopathology)
• Neural Conduction
• Neurons, Afferent
• Postoperative Period
• Recovery of Function
• Time Factors