Abstract |
Between January 2000 and December 2001, renal involvement in 81 cases of malaria was studied. Their age ranged between 05 and 66 (mean 35.5) years. Distribution of malarial parasite was P falciparum (75), mixed infection (4) and P vivax (2). The evidence of clinical renal disease in the form of acute renal failure, electrolyte abnormality, abnormal urinary sediment and increased urinary protein excretion (>500 mg/24 hours) was found in 100%, 91.3%, 46.9% and 18.5% respectively. Probable aetiopathogenesis of acute renal failure (ARF) was multifactorial. Volume depletion (72.8%) was the dominant cause of ARF in these patients. In addition, hyperbilirubinaemia, intravascular haemolysis and sepsis were responsible for ARF in 64.2%, 70.3% and 25.9% cases respectively. All the patients were managed with anti-malarial drugs and dialysis support was needed in 35 patients (43.2%). Prognosis of malarial acute renal failure is favourable with mortality rate of 18.5%. Multi-organ failure was the commonest cause (33.3%) of death.
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Authors | Amit Maheshwari, A K Singh, D K Sinha, K Tripathi, Jai Prakash |
Journal | Journal of the Indian Medical Association
(J Indian Med Assoc)
Vol. 102
Issue 3
Pg. 143, 146, 148 passim
(Mar 2004)
ISSN: 0019-5847 [Print] India |
PMID | 15473274
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Acute Kidney Injury
(etiology, physiopathology)
- Adolescent
- Adult
- Aged
- Antimalarials
(therapeutic use)
- Child
- Child, Preschool
- Female
- Humans
- Hypovolemia
(etiology)
- Malaria, Falciparum
(complications, drug therapy)
- Malaria, Vivax
(complications, drug therapy)
- Male
- Middle Aged
- Prognosis
- Sepsis
(etiology)
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