| Abstract |
The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and alphaB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice. |
| Authors | Joon Shik Shin, Chang Sok So, Young Ock Kim, Duk Kyun Ahn, Kaizhi G Sharman, Edward H Sharman |
| Journal | The International journal of neuroscience
(Int J Neurosci)
Vol. 114
Issue 10
Pg. 1365-88
(Oct 2004)
ISSN: 0020-7454 [Print] England |
| PMID | 15370193
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Endoplasmic Reticulum Chaperone BiP
- Heat-Shock Proteins
- Hspa5 protein, mouse
- Immediate-Early Proteins
- Molecular Chaperones
- Muscarinic Antagonists
- Plant Extracts
- Plant Preparations
- RNA, Messenger
- Transcription Factors
- youkongdan
- Scopolamine
- Sod1 protein, mouse
- Sod1 protein, rat
- Superoxide Dismutase
- Superoxide Dismutase-1
- Mitogen-Activated Protein Kinase Kinases
|
| Topics |
- Age Factors
- Animals
- Behavior, Animal
(drug effects)
- Brain Ischemia
(prevention & control)
- Cell Count
(methods)
- Cerebral Cortex
(drug effects)
- DNA-Binding Proteins
(genetics, metabolism)
- Dietary Supplements
- Drug Interactions
- Early Growth Response Protein 1
- Endoplasmic Reticulum Chaperone BiP
- Exploratory Behavior
(drug effects)
- Female
- Gene Expression Regulation
(drug effects)
- Heat-Shock Proteins
(genetics, metabolism)
- Hippocampus
(drug effects, pathology)
- Immediate-Early Proteins
(genetics, metabolism)
- Male
- Maze Learning
(drug effects)
- Memory
(drug effects)
- Mice
- Mice, Inbred Strains
- Mitogen-Activated Protein Kinase Kinases
(genetics, metabolism)
- Molecular Chaperones
(genetics, metabolism)
- Motor Activity
(drug effects)
- Muscarinic Antagonists
(therapeutic use)
- Oligonucleotide Array Sequence Analysis
(methods)
- Phytotherapy
(methods)
- Plant Extracts
(pharmacology, therapeutic use)
- Plant Preparations
(pharmacology, therapeutic use)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Wistar
- Reaction Time
(drug effects)
- Scopolamine
(therapeutic use)
- Superoxide Dismutase
(genetics, metabolism)
- Superoxide Dismutase-1
- Transcription Factors
(genetics, metabolism)
|
