Effect of M4-cholinoceptor blockade on haloperidol-produced catatonic syndrome in rats.

Abstract

We studied the relationship between the efficiency of muscarinic receptor antagonists in preventing haloperidol-induced catatonia and their activity in tests for the interaction of ligands with various subtypes of muscarinic receptors (M1-M4) in rats. Mathematical modeling showed that affinity of the ligand for M4 receptors positively affects its ability to correct extrapyramidal disorders (catatonic syndrome) produced by haloperidol, while affinity for M2 receptors had a negative effect on this characteristic.

• Authors: S G Dagaev, A B Kosmachev, O A Filko, L G Kubarskaya, A V Khrabrova, V A Beliaev, N P Podosinovikova, N M Libman, V I Sanotskii, V B Dolgo-Saburov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 137 Issue 2 Pg. 152-4 (Feb 2004) ISSN: 0007-4888 [Print] United States
• PMID: 15273762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ligands
• Muscarinic Antagonists
• Receptor, Muscarinic M4
• Receptors, Muscarinic
• Pilocarpine
• Haloperidol

Topics

• Animals
• Basal Ganglia Diseases (chemically induced, metabolism, prevention & control)
• Catatonia (chemically induced, metabolism, prevention & control)
• Haloperidol (toxicity)
• Kinetics
• Ligands
• Male
• Models, Biological
• Muscarinic Antagonists (pharmacology)
• Pilocarpine (pharmacology)
• Rats
• Receptor, Muscarinic M4 (antagonists & inhibitors, metabolism)
• Receptors, Muscarinic (classification, metabolism)
• Syndrome