Targeting the chemokine network in renal inflammation.

Abstract

Chemokines and their receptors are involved in the pathogenesis of renal diseases. They mediate leukocyte recruitment and activation during initiation as well as progression of renal inflammation. Infiltrating leukocyte subpopulations contribute to renal damage by releasing inflammatory and profibrotic cytokines. All intrinsic renal cells are capable of chemokine secretion on stimulation in vitro. Expression of inflammatory chemokines correlates with renal damage and local accumulation of chemokine receptor-bearing leukocytes in a variety of animal models of renal diseases as well as in human biopsy studies. Chemokines and their respective receptors could represent new targets for therapeutic intervention in renal inflammatory disease states that often tend to progress to end-stage renal disease. This article summarizes the present data on the role of chemokines and their receptors in renal inflammation with special emphasis on our efforts to identify the chemokine receptors CCR1 and CCR2 as promising targets for therapeutic intervention.

• Authors: Vaclav Eis, Volker Vielhauer, Hans-Joachim Anders
• Journal: Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) 2004 May-Jun Vol. 52 Issue 3 Pg. 164-72 ISSN: 0004-069X [Print] Switzerland
• PMID: 15247883 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• CCR1 protein, human
• CCR2 protein, human
• Chemokines
• Receptors, CCR1
• Receptors, CCR2
• Receptors, Chemokine

Topics

• Animals
• Chemokines (immunology)
• Humans
• Inflammation (immunology)
• Kidney Diseases (immunology)
• Leukocytes (metabolism)
• Receptors, CCR1
• Receptors, CCR2
• Receptors, Chemokine (immunology)