Hydrops fetalis associated with homozygosity for hemoglobin Taybe (alpha 38/39 THR deletion) in newborn triplets.

Abstract

Hemoglobin Taybe is an unstable alpha-chain hemoglobin variant caused by a deletion of a threonine residue at codon 38 or 39 of the alpha-1 globin chain. We describe preterm infant triplets born with hydrops fetalis and anemia who were found by DNA analysis to be homozygous for hemoglobin Taybe. All three infants developed intrauterine hemolytic anemia, which subsequently led to hydrops fetalis. To the best of our knowledge, this is the first description of hydrops fetalis associated with this hemoglobinopathy. We suggest that hemoglobin Taybe be considered in the differential diagnosis of hydrops fetalis and that known affected fetuses be carefully followed both antenatally and postnatally.

• Authors: Shmuel Arnon, Hannah Tamary, Orly Dgany, Ita Litmanovitz, Rivka Regev, Sofia Bauer, Tzipora Dolfin, Joanne Yacobovich, Baruch Wolach, Lutfi Jaber
• Journal: American journal of hematology (Am J Hematol) Vol. 76 Issue 3 Pg. 263-6 (Jul 2004) ISSN: 0361-8609 [Print] United States
• PMID: 15224363 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Chemical References

• Hemoglobins, Abnormal
• hemoglobin Taybe
• Globins
• DNA

Topics

• Adult
• Anemia, Hemolytic (genetics)
• Consanguinity
• DNA (blood)
• Erythrocyte Transfusion
• Female
• Fetal Diseases (genetics)
• Gene Deletion
• Globins (genetics)
• Hemoglobins, Abnormal (genetics)
• Homozygote
• Humans
• Hydrops Fetalis (blood, genetics)
• Infant, Newborn
• Infant, Premature
• Intensive Care, Neonatal
• Male
• Polymerase Chain Reaction
• Pregnancy
• Triplets