Abstract | BACKGROUND: METHODS: Patients are eligible when they have ischemia during an ETT and AECG monitoring and when their fasting total cholesterol level is < or =250 mg/dL. Eligible patients are randomized to receive 1 of 3 treatments: intensive atorvastatin to reduce LDL cholesterol level to < or =80 mg/dL, intensive atorvastatin to reduce LDL cholesterol level to < or =80 mg/dL plus antioxidant vitamins C and E, and control of diet and low-dose lovastatin, when needed, to reduce LDL cholesterol level < or = to 130 mg/dL. Patients undergo endothelial function testing, 48-hour AECG monitoring, and ETT at randomization and at 6 and 12 months. RESULTS: A total of 300 patients have been randomized: 101 to receive atorvastatin alone, 103 to receive atorvastatin plus antioxidant vitamins, and 96 to receive placebo. Baseline characteristics are similar across treatment groups. CONCLUSIONS: The Vascular Basis study will provide important insight on the effects of aggressive management of dyslipidemia with statin drugs and antioxidant vitamins in patients with stable but high-risk CAD.
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Authors | Peter H Stone, Donald M Lloyd-Jones, Michael Johnstone, William Carlson, Joel Rubenstein, Mark Creager, Balz Frei, George Sopko, Maureen E Clark, Gail Maccallum, Scott Kinlay, John Orav, Andrew P Selwyn |
Journal | American heart journal
(Am Heart J)
Vol. 147
Issue 5
Pg. 875-82
(May 2004)
ISSN: 1097-6744 [Electronic] United States |
PMID | 15131545
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticholesteremic Agents
- Antioxidants
- Cholesterol, LDL
- Heptanoic Acids
- Pyrroles
- Vitamin E
- Atorvastatin
- Ascorbic Acid
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anticholesteremic Agents
(therapeutic use)
- Antioxidants
(therapeutic use)
- Ascorbic Acid
(therapeutic use)
- Atorvastatin
- Brachial Artery
(diagnostic imaging)
- Cholesterol, LDL
(blood)
- Double-Blind Method
- Female
- Heptanoic Acids
(therapeutic use)
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(blood, drug therapy)
- Pyrroles
(therapeutic use)
- Regional Blood Flow
- Ultrasonography
- Vasodilation
- Vitamin E
(therapeutic use)
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