Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans.

Abstract

UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immunoreactivity do not co-localize in the pons of patients with PSP. As HSPs are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of PSP and other tauopathies.

• Authors: Andrew D Hope, Tammaryn Lashley, Andrew J Lees, Rohan de Silva
• Journal: Neuroscience letters (Neurosci Lett) Vol. 359 Issue 1-2 Pg. 94-8 (Apr 08 2004) ISSN: 0304-3940 [Print] Ireland
• PMID: 15050720 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heat-Shock Proteins
• UBB protein, human
• Ubiquitin

Topics

• Aged
• Aged, 80 and over
• Female
• Gene Expression Regulation (physiology)
• Heat-Shock Proteins (biosynthesis, genetics)
• Humans
• Male
• Middle Aged
• Pons (metabolism, pathology)
• Supranuclear Palsy, Progressive (metabolism, pathology)
• Ubiquitin (biosynthesis, genetics)