Abstract | BACKGROUND & OBJECTIVE: METHODS: The expression of hTERT mRNA in 113 NSCLC specimens were detected by in situ hybridization, and the expression of c-myc, mutant p53, and PKCalpha in the same specimens were detected by immunohistochemistry. RESULTS: The positive rates of 113 NSCLC samples for hTERT mRNA, c-myc, mutant p53, and PKCalpha were 80.5%, 68.1%, 61.9%, and 85.0%, respectively. The differences were statistically significant among the expression of hTERT mRNA, c-myc, and PKCalpha (P< 0.05 or P< 0.01), but was not significant between the expression of mutant p53 and hTERT mRNA, c-myc as well as PKCalpha. The expression of mutant p53 was associated with carcinoma cell differentiation (P< 0.05), and its positive rate gradually increased with the extend of differentiation of carcinoma cell. The expression of hTERT mRNA, c-myc, and PKCalpha were not associated with carcinoma cell differentiation. There was no relationship of expression of the four markers with histological types, TNM stages, and lymph node metastasis status. CONCLUSION: C-myc and PKCalphawere associated with the expression of telomerase.
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Authors | Tao-Xiang Chen, Yong-Yan Xiong, Lin Liu |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 23
Issue 3
Pg. 273-7
(Mar 2004)
China |
PMID | 15025956
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA-Binding Proteins
- RNA, Messenger
- PRKCA protein, human
- Protein Kinase C
- Protein Kinase C-alpha
- Telomerase
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Topics |
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(enzymology, genetics, pathology)
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Enzymologic
- Genes, myc
- Genes, p53
- Humans
- Lung Neoplasms
(enzymology, genetics, pathology)
- Male
- Middle Aged
- Mutation
- Protein Kinase C
(analysis)
- Protein Kinase C-alpha
- RNA, Messenger
(analysis)
- Telomerase
(genetics)
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