Abstract |
A double-blind, vehicle control, parallel clinical trial evaluated the effectiveness and safety of the local application of flunisolide, a potent new topical steroid, in the treatment of ragweed hay fever. Fifty patients with well-defined, poorly controlled ragweed allergy were studied during the 1974 ragweed season. Analysis of the data showed that the active drug group had a significant decrease in individual symptoms of sneezing, nasal stuffiness, and nasal secretions, compared with the placebo group. Antihistamine usage was statistically decreased in the active drug over placebo group. There was no evidence of adrenal suppression. This study indicates that intranasal administration of flunisolide in adult patients is both efficacious and safe in the treatment of seasonal allergic rhinitis.
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Authors | J K Kammermeyer, D W Rajtora, J Anuras, H B Richerson |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 59
Issue 4
Pg. 287-93
(Apr 1977)
ISSN: 0091-6749 [Print] United States |
PMID | 14982
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Histamine H1 Antagonists
- Fluocinolone Acetonide
- flunisolide
- Hydrocortisone
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Topics |
- Administration, Intranasal
- Adolescent
- Adult
- Clinical Trials as Topic
- Drug Evaluation
- Drug Therapy, Combination
- Female
- Fluocinolone Acetonide
(administration & dosage, analogs & derivatives, therapeutic use)
- Histamine H1 Antagonists
(therapeutic use)
- Humans
- Hydrocortisone
(blood)
- Male
- Rhinitis, Allergic, Seasonal
(blood, drug therapy)
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