[Heparin Surface-Modified Poly(methylmethacrylate) and Foldable Hydrophobic Acrylic Intraocular Lenses in Cataract Patients with Acquired Immune Deficiency Syndrome and CMV-Retinitis].

Abstract

BACKGROUND:

In HIV-positive patients with necrotising retinitis, well-tolerated lens material as well as minimal invasive surgery to avoid postoperative complications are imperative. Heparin surface-modified PMMA-IOLs as well as acrylic IOLs are associated with less postoperative inflammation than conventional intraocular lenses.

METHODS:

In this randomised prospective clinical trial 18 patients received 7 HSM-IOLs through a self-sealing scleral tunnel and 11 foldable Acrysof-IOLs through a self-sealing limbal tunnel incision by the same surgeon. 7 of the 18 eyes were silicone oil-filled before cataract surgery, one eye received oil after the IOL implantation. Visual acuity, intraocular pressure, contrast sensitivity, intraocular inflammation and posterior capsule opacification were assessed. The follow-up period was 1 year.

RESULTS:

Eyes with Acrysof-IOLs were associated with lower, but not statistically significant, laser flare photometry values (photon counts/ms) than those with HSM-IOLs pre- (90.18 +/- 54.7 vs. 73.92 +/- 6.44) and 3 months post-surgery (69.06 +/- 8.27 vs. 55.03 +/- 7.75). 6 of the 7 eyes with HSM-IOL and 3 eyes of the Acrysof-group developed a dense posterior capsule opacification (PCO), 2 eyes had no and 6 eyes only a distinct PCO. YAG capsulotomy did not improve visual acuity in any case but retinal examination was again possible. Eyes with Acryl-IOL showed pre- and postoperatively a better visual acuity than eyes with HSM-IOL ("hand movement" - 0.4 vs. "no light perception" - 0.1 pre- and 0.05 - 0.6 vs. "no light perception" - 0.1 3 months postoperatively. Contrast sensitivity testing (Vistech method) could be performed in the PMMA-group preoperatively only in 1 eye (A1), in the Acryl-group in 2 eyes (A4, B4, C2, D2) and revealed postoperatively "no contrast vision" - A1, B2, C1 vs. "no contrast vision" - A2, B2, C3, D1, E1. The intraocular pressure was preoperatively 13.86 mm Hg (PMMA) vs. 14.82 mm Hg (Acrysof) and 14.4 mm Hg vs. 12.89 mm Hg 3 months post surgery.

CONCLUSION:

In the parameters we observed there was no statistical significant difference between heparin-surface modified (Pharmacia 811 C) and hydrophobic acrylic IOLs (Alcon Acrysof MA60BM) in patients with AIDS. As foldable Acrysof-IOLs can be implanted through a self-sealing bloodless tunnel incision and are associated with less posterior capsule opacification we prefer this IOL type in cataract surgery of AIDS patients.

• Authors: Susanne Krieglsteiner, Herrmann O C Gümbel, Thomas Kohnen
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 221 Issue 1 Pg. 40-6 (Jan 2004) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Heparinbeschichtete Polymethylmethacrylat- und faltbare hydrophobe Acrylatintraokularlinsen bei Kataraktpatienten mit erworbenem Immundefektsyndrom und CMV-Retinitis.
• PMID: 14745677 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Acrylates
• Coated Materials, Biocompatible
• Silicone Oils
• Polymethyl Methacrylate

Topics

• AIDS-Related Opportunistic Infections (complications)
• Acquired Immunodeficiency Syndrome (complications)
• Acrylates
• Adult
• Coated Materials, Biocompatible
• Cytomegalovirus Retinitis (complications)
• Equipment Failure Analysis
• Female
• Humans
• Hydrophobic and Hydrophilic Interactions
• Keratitis, Herpetic (surgery)
• Male
• Middle Aged
• Polymethyl Methacrylate
• Postoperative Complications (etiology, prevention & control)
• Prosthesis Design
• Reoperation
• Retinal Detachment (surgery)
• Retinal Necrosis Syndrome, Acute (complications)
• Risk Factors
• Silicone Oils (administration & dosage, adverse effects)