Abstract | BACKGROUND: METHODS: RESULTS: The overall prevalence of aPL antibodies was 26%. In follow-up, 79% of aPL antibody-positive patients experienced thrombotic events and/or fetal losses, and aPL antibodies were associated significantly with arterial or venous thrombosis (P = 0.00001), pregnancy morbidity (P = 0.045), thrombocytopenia (P = 0.0015), and persistent arterial hypertension (P = 0.028). aPL antibodies were significantly more frequent in patients with biopsy-proven membranous lupus nephritis (P = 0.01). A strong association between aPL antibodies and the development of chronic renal insufficiency in the long-term outcome also was found (P = 0.01). With multivariate analysis, aPL antibody positivity (P = 0.02), high plasma creatinine level at presentation (P = 0.01), and chronicity index (P = 0.00004) were independent predictors of chronic renal function deterioration. CONCLUSION: Detection of aPL antibodies in patients with lupus nephritis is useful not only to identify patients at risk for vascular and obstetric manifestations, but also for their potential deleterious impact on renal outcome.
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Authors | Gabriella Moroni, Donatella Ventura, Paola Riva, Paola Panzeri, Silvana Quaglini, Giovanni Banfi, Paola Simonini, Rossella Bader, Pier Luigi Meroni, Claudio Ponticelli |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 43
Issue 1
Pg. 28-36
(Jan 2004)
ISSN: 1523-6838 [Electronic] United States |
PMID | 14712424
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antiphospholipid
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Topics |
- Adolescent
- Adult
- Antibodies, Antiphospholipid
(blood)
- Disease-Free Survival
- Female
- Fetal Death
- Humans
- Kidney Failure, Chronic
(etiology)
- Lupus Erythematosus, Systemic
(complications, immunology)
- Lupus Nephritis
(complications, immunology)
- Male
- Middle Aged
- Multivariate Analysis
- Pregnancy
- Pregnancy Outcome
- Prospective Studies
- Risk Factors
- Thrombosis
(etiology, immunology)
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