Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2.

Abstract	Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas, are rare entities that have only been recently recognized and characterized. These lymphomas often show an aggressive clinical course. We investigated the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in 3 CD56+CD4+ and 4 CD8+ cutaneous T-cell lymphomas. HLA-G expression was detected in 2 of 3 lymphomas of the CD56+CD4+ type and in all lymphomas of CD8+ type. It is of note that CD56+CD4+ lymphomas displayed stronger HLA-G reactivity. The expression of IL-10 matched the expression of HLA-G. Together with the expression of IL-10, HLA-G might be one of the factors accounting for the evasion of immunosurveillance, thus contributing to aggressive phenotype of these lymphoma entities.
Authors	Mirjana Urosevic, Jivko Kamarashev, Günter Burg, Reinhard Dummer
Journal	Blood (Blood) Vol. 103 Issue 5 Pg. 1796-8 (Mar 01 2004) ISSN: 0006-4971 [Print] United States
PMID	14592815 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antigens, CD CD56 Antigen CD8 Antigens HLA Antigens HLA-G Antigens Histocompatibility Antigens Class I LILRB1 protein, human Leukocyte Immunoglobulin-like Receptor B1 Receptors, Immunologic Interleukin-10
Topics	Adult Aged Antigens, CD (biosynthesis) CD56 Antigen (biosynthesis) CD8 Antigens (biosynthesis) Female HLA Antigens (biosynthesis) HLA-G Antigens Histocompatibility Antigens Class I (biosynthesis) Humans Immunohistochemistry Interleukin-10 (biosynthesis) Killer Cells, Natural (cytology, metabolism) Leukocyte Immunoglobulin-like Receptor B1 Lymphoma (metabolism, pathology) Lymphoma, T-Cell (metabolism) Male Middle Aged Phenotype Receptors, Immunologic (biosynthesis) Skin Neoplasms (metabolism, pathology)

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