LDL phenotype B and other lipid abnormalities in patients with large vessel disease and small vessel disease.

Abstract

BACKGROUND AND PURPOSE:

Controversies concerning the significance of lipid abnormalities in stroke come mostly from the researches that studied lipid profile without considering stroke aetiologies. We investigated the prevalence of LDL phenotype B and other lipid abnormalities in stroke survivors with large vessel disease (LVD) or small vessel disease (SVD) (TOAST criteria) and in control subjects (CS).

METHODS:

We studied 30 patients with LVD and 41 patients with SVD screened out of 585 stroke patients and 30 CS who fulfilled the following exclusion criteria: cardiac disorders, renal or hepatic failure, diabetes mellitus, or treatment with lipid-lowering agents. At least 3 months after stroke, the concentrations of total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), apolipoprotein E (apoE), and lipoprotein (a) [lp(a)] were measured and LDL phenotypes and apoE isoforms were identified.

RESULTS:

Patients with LVD had significantly higher concentrations of LDL-C than CS (p<0.05). They had higher concentrations of TGs and lower concentrations of HDL-C than patients with SVD and CS (p<0.05). LDL phenotype B was more frequent in patients with LVD (63.3%) than in patients with SVD (39.0%) or in CS (16.7%) (p<0.05). The concentration of apoE was higher in patients with LVD than in patients with SVD or in CS (p<0.05). The percentage of patients with increased level of lp(a) (i.e., >30 mg/ml) was greater in patients with LVD (36.7%) than in CS (10%) (p<0.05).

CONCLUSIONS:

Patients with stroke due to LVD, but not SVD, have high prevalence of atherogenic lipid abnormalities, including increased frequency of LDL phenotype B and higher percentage of increased lp(a) level, like patients with other atherogenic diseases.

• Authors: Agnieszka Slowik, Tomasz Iskra, Wojciech Turaj, Jadwiga Hartwich, Aldona Dembinska-Kiec, Andrzej Szczudlik
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 214 Issue 1-2 Pg. 11-6 (Oct 15 2003) ISSN: 0022-510X [Print] Netherlands
• PMID: 12972382 (Publication Type: Journal Article)

Chemical References

• Apolipoproteins E
• Cholesterol, HDL
• Cholesterol, LDL
• Lipoprotein(a)
• Triglycerides
• Cholesterol

Topics

• Aged
• Apolipoproteins E (blood)
• Brain Ischemia (blood, epidemiology, genetics)
• Cerebral Arteries (pathology, physiopathology)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood, genetics)
• Female
• Humans
• Hyperlipidemias (blood, epidemiology, genetics)
• Intracranial Arteriosclerosis (blood, epidemiology, genetics)
• Lipoprotein(a) (blood)
• Male
• Middle Aged
• Phenotype
• Prevalence
• Risk Factors
• Stroke (blood, epidemiology, genetics)
• Triglycerides (blood)