Abstract | BACKGROUND AND OBJECTIVES: Women undergoing assisted reproductive procedures, such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), fail to achieve pregnancy in approximately 70% of cases. Postulating that among the possible causes of failure of embryo implantation might be an impairment of the uteroplacental circulation due to hypercoagulability in the mother, we investigated the association between thrombophilia and failure to achieve pregnancy after IVF or ICSI. DESIGN AND METHODS: RESULTS: INTERPRETATION AND CONCLUSIONS: This study provides no evidence for an association between maternal thrombophilia and failure to achieve pregnancy after assisted reproductive procedures. Routine anticoagulant treatment in women undergoing assisted reproductive procedures is not warranted.
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Authors | Ida Martinelli, Emanuela Taioli, Guido Ragni, Paolo Levi-Setti, Serena Maria Passamonti, Tullia Battaglioli, Corrado Lodigiani, Pier Mannuccio Mannucci |
Journal | Haematologica
(Haematologica)
Vol. 88
Issue 7
Pg. 789-93
(Jul 2003)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 12857558
(Publication Type: Journal Article)
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Chemical References |
- Factor V
- Prothrombin
- Oxidoreductases Acting on CH-NH Group Donors
- Methylenetetrahydrofolate Reductase (NADPH2)
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Topics |
- Adolescent
- Adult
- Case-Control Studies
- Embryo Implantation
- Factor V
(genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Mutation
- Oxidoreductases Acting on CH-NH Group Donors
(genetics)
- Pregnancy
- Pregnancy Outcome
- Prothrombin
(genetics)
- Reproductive Techniques, Assisted
- Thrombophilia
(complications, genetics)
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