Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.

Abstract

Antiviral properties of betulin, betulinic and betulonic acids were investigated in cell cultures infected with herpes simplex type I, influenza FPV/Rostock and ECHO 6 viruses. All studied triterpenes were active against herpes simplex virus. Betulin and especially betulinic acid also suppressed ECHO 6 virus reproduction.

• Authors: N I Pavlova, O V Savinova, S N Nikolaeva, E I Boreko, O B Flekhter
• Journal: Fitoterapia (Fitoterapia) Vol. 74 Issue 5 Pg. 489-92 (Jul 2003) ISSN: 0367-326X [Print] Netherlands
• PMID: 12837369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Pentacyclic Triterpenes
• Plant Extracts
• Triterpenes
• Viral Envelope Proteins
• betulonic acid
• Oleanolic Acid
• betulin
• Betulinic Acid

Topics

• Antiviral Agents (administration & dosage, pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Echovirus 6, Human (drug effects)
• Herpesvirus 1, Human (drug effects)
• Humans
• Influenza A virus (drug effects)
• Microbial Sensitivity Tests
• Oleanolic Acid (administration & dosage, analogs & derivatives, pharmacology, therapeutic use)
• Pentacyclic Triterpenes
• Phytotherapy
• Plant Bark
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Triterpenes (administration & dosage, pharmacology, therapeutic use)
• Tumor Cells, Cultured (drug effects)
• Viral Envelope Proteins
• Betulinic Acid