Abstract | BACKGROUND: Solid malignant tumours are still associated with high mortality and morbidity. Chemoprevention--long-term systemic therapy in order to revert, stop or at least delay the carcinogenic process--is a feasible therapeutic approach to persons at increased risk of cancer. METHODS: References for this review article were identified by a search of Medline and PubMed for the years 1990 to 2002; the keywords used were " chemoprevention", " tamoxifen", " COX-2 inhibitors", " NSAIDs", " SERM", "EGFR", " breast cancer", "familial adenomatous polyposis coli", " colorectal cancer", " lung cancer", and " prostate cancer". RESULTS: Long-term medical treatment of persons at high-risk of cancer may reduce the incidence of several types of malignancies. This approach requires early and reliable identification of persons at high risk. INTERPRETATION:
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Authors | Jon Sudbø |
Journal | Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
(Tidsskr Nor Laegeforen)
Vol. 123
Issue 11
Pg. 1514-7
(May 29 2003)
ISSN: 0807-7096 [Electronic] Norway |
Vernacular Title | Kjemoprevensjon--primaerforebyggende behandling ved høy kreftrisiko. |
PMID | 12822011
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Anticarcinogenic Agents
- Cyclooxygenase Inhibitors
- Selective Estrogen Receptor Modulators
- Tamoxifen
- ErbB Receptors
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Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Anticarcinogenic Agents
(administration & dosage)
- Breast Neoplasms
(genetics, prevention & control)
- Chemoprevention
(methods)
- Colorectal Neoplasms
(genetics, prevention & control)
- Cyclooxygenase Inhibitors
(administration & dosage)
- Drug Therapy, Combination
- ErbB Receptors
(antagonists & inhibitors, drug effects)
- Female
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
(genetics, prevention & control)
- Male
- Primary Prevention
(methods)
- Risk Factors
- Selective Estrogen Receptor Modulators
(administration & dosage)
- Tamoxifen
(administration & dosage)
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