Abstract |
Information on the impact of insecticide ( permethrin)-treated bed nets (ITNs) from randomized controlled trials in areas of intense perennial malaria transmission is limited. As part of a large-scale, community-based, group-randomized controlled trial of the effect of ITNs on childhood mortality in a holoendemic area in western Kenya, we conducted three cross-sectional surveys in 60 villages to assess the impact of ITNs on morbidity in 1,890 children less than three years old. Children in ITN and control villages were comparable pre-intervention, but after the introduction of ITNs, children in intervention villages were less likely to have recently experienced illness requiring treatment (protective efficacy [95% confidence intervals] = 15% [1-26%]), have an enlarged spleen (32% [20-43%]), be parasitemic (19% [11-27%]), have clinical malaria (44% [6-66%]), have moderately severe anemia ( hemoglobin level < 7.0 g/dL; 39% [18-54%]), or have a pruritic body rash, presumably from reduced nuisance insect bites (38% [24-50%]). Use of ITNs was also associated with significantly higher mean weight-for-age Z-scores and mid-upper arm circumferences. There was no evidence, however, that ITNs reduced the risk of helminth infections, diarrhea, or upper or lower respiratory tract infections. The ITNs substantially reduced malaria-associated morbidity and improved weight gain in young children in this area of intense perennial malaria transmission.
|
Authors | Feiko O ter Kuile, Dianne J Terlouw, Penelope A Phillips-Howard, William A Hawley, Jennifer F Friedman, Margarette S Kolczak, Simon K Kariuki, Ya Ping Shi, Arthur M Kwena, John M Vulule, Bernard L Nahlen |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 68
Issue 4 Suppl
Pg. 100-7
(Apr 2003)
ISSN: 0002-9637 [Print] United States |
PMID | 12749492
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
|
Topics |
- Bedding and Linens
- Child, Preschool
- Cross-Sectional Studies
- Female
- Health Status
- Health Surveys
- Humans
- Infant
- Insecticides
(pharmacology)
- Kenya
(epidemiology)
- Malaria
(epidemiology, prevention & control, transmission)
- Male
- Medical History Taking
- Morbidity
- Permethrin
(pharmacology)
|