[Clinical analysis of endoscopy negative gastroesophageal reflux disease in the elderly].

Abstract

The purpose of this study was to describe the clinical analysis of endoscopy negative gastroesophageal reflux disease (EN-GERD) in the elderly. 35 elderly patients of both sexes, 60 years or older with EN-GERD, 33 elderly patients with reflux esophagitis and 41 elderly patients as control group were included in this study. All patients witnessed verbal informed consent to participate in the study. EN-GERD was defined as the patients with normal endoscopy despite of heartburn as their chief complaint and who were completely relieved with heartburn after one-week omeprazole treatment. Helicobacter pylori infection between EN-GERD, reflux esophagitis and control were 37.1%, 24.2% and 56.1%, respectively. The gastric mucosal atrophy under endoscopic findings and the serum pepsinogen I, II ratio in EN-GERD had no significant differences with control. A hiatus hernia with EN-GERD was diagnosed 37.1%, which was lower significantly than 87.9% with reflux esophagitis. The motility of the stomach using the acetaminophen method was the same in patients with EN-GERD, reflux esophagitis and control. The anxiety score of the Hospital Anxiety and Depression Scale was significantly higher in the patients with EN-GERD than in those with reflux esophagitis and control. On the other hand, the severity of reflux symptoms in the patients with EN-GERD was similar as those with reflux esophagitis. We concluded that general anxiety plays an important role in the severity of the reflux symptoms in the patients with EN-GERD. As such symptoms in EN-GERD significantly impair the quality of life, further studies of patients with EN-GERD are greatly needed.

• Authors: Takafumi Yamamoto, Jun Matsumoto, Terukatsu Arima
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 100 Issue 3 Pg. 306-12 (Mar 2003) ISSN: 0446-6586 [Print] Japan
• PMID: 12696171 (Publication Type: Journal Article)

Topics

• Aged
• Endoscopy, Digestive System
• Female
• Gastric Acid (metabolism)
• Gastroesophageal Reflux (diagnosis, physiopathology, psychology)
• Helicobacter Infections (complications)
• Helicobacter pylori
• Hernia, Hiatal (complications)
• Humans
• Male
• Manifest Anxiety Scale
• Middle Aged
• Severity of Illness Index