[Anesthetic management of a patient with congenital plasminogen activator inhibitor-1 deficiency].

Abstract

Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis due to hyperfibrinolysis as a result of decreased PAI-1 activity. A 21-year-old male with congenital PAI-1 deficiency underwent wisdom teeth extraction of the mandible under general anesthesia using propofol, nitrous oxide, sevoflurane, fentanyl, and vecuronium. No complications including prolonged bleeding and rebleeding after the operation were observed because hemostatic management was successful by using intravenous tranexamic acid.

• Authors: Atsuhisa Kajihara, Hiroyoshi Kurehara, Katsuyasu Kitaguchi, Hitoshi Furuya, Yoshinari Morimoto, Tadaaki Kirita, Kazuyoshi Fukuda, Yukihiro Takahashi
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 52 Issue 1 Pg. 73-5 (Jan 2003) ISSN: 0021-4892 [Print] Japan
• PMID: 12632627 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antifibrinolytic Agents
• Plasminogen Activator Inhibitor 1
• Tranexamic Acid

Topics

• Adult
• Anesthesia, General
• Antifibrinolytic Agents (administration & dosage)
• Blood Loss, Surgical (prevention & control)
• Humans
• Male
• Molar, Third (surgery)
• Perioperative Care
• Plasminogen Activator Inhibitor 1 (deficiency)
• Tooth Extraction
• Tranexamic Acid (administration & dosage)
• Treatment Outcome