[Clinical observation on effect of shenle capsule in treating mesangial proliferating glomerulonephritis].

Abstract

OBJECTIVE:

To study the therapeutic effect of Shenle capsule (SLC) in treating mesangial proliferating glomerulonephritis (MsPGN) and to explore its therapeutic mechanism and clinical indication.

METHODS:

Adopting case control method, taking angiotensin-converting enzyme inhibitor (benazepril) as control agent, the 142 cases of MsPGN were randomly divided into 3 groups, treated with SLC (Group A, n = 36), SLC plus benazepril (Group B, n = 68) and benazepril alone (Group C, n = 38) respectively. Changes of fibrinogen, lipids, renal function and urinary protein were observed.

RESULTS:

The total effective rate in Group A was higher than that in Group C, but with insignificant difference. The total effective rate in Group B after 3 courses of treatment was 89.74%, which was higher than that in Group C and Group A (P < 0.05). Levels of cholesterol (CH), triglyceride (TG), serum creatinine, fibrinogen and urinary protein (UP) were significantly lowered in Group A after treatment, with the levels of CH, TG and UP lower than those in Group C, while CH, TG and fibrinogen were unchanged in Group C after treatment.

CONCLUSION:

SLC is superior in higher efficacy and less side-effects in treating MsPGN, its effect is related with the degree of kidney pathological changes, it is more effective in treating patients with mild pathological change than in those with severe change. The outcome of combined use of SLC and angiotensin-converting enzyme inhibitor would be better.

• Authors: Chen-yun Wei, Xiang-mei Chen, Yan-ping Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 22 Issue 5 Pg. 341-5 (May 2002) ISSN: 1003-5370 [Print] China
• PMID: 12584830 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Benzazepines
• Drugs, Chinese Herbal
• Triglycerides
• Cholesterol
• benazepril

Topics

• Adolescent
• Adult
• Aged
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Benzazepines (therapeutic use)
• Child
• Cholesterol (blood)
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Glomerulonephritis, Membranoproliferative (blood, drug therapy)
• Humans
• Male
• Middle Aged
• Phytotherapy
• Proteinuria (drug therapy)
• Triglycerides (blood)