Lipoarabinomannan-reactive human secretory immunoglobulin A responses induced by mucosal bacille Calmette-Guérin vaccination.

Abstract

The ability of 17 recombinant mycobacterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis lysate to detect antibody responses induced by bacille Calmette-Guérin (BCG) vaccination and active tuberculosis infection were studied in enzyme-linked immunosorbent assays. Only LAM-reactive serum immunoglobulin G responses were significantly increased in both BCG-vaccinated patients and patients with active tuberculosis (P<.05), and oral BCG vaccination also induced significant increases in LAM-reactive secretory immunoglobulin A (P<.05). LAM-reactive antibody assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer attenuated mycobacterial vaccines.

• Authors: Robin M Brown, Orlando Cruz, Michael Brennan, Maria L Gennaro, Larry Schlesinger, Yasir A W Skeiky, Daniel F Hoft
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 187 Issue 3 Pg. 513-7 (Feb 01 2003) ISSN: 0022-1899 [Print] United States
• PMID: 12552438 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• BCG Vaccine
• Immunoglobulin A
• Lipopolysaccharides
• lipoarabinomannan

Topics

• Adolescent
• Adult
• BCG Vaccine (immunology)
• Female
• Humans
• Immunoglobulin A (immunology)
• Lipopolysaccharides (immunology)
• Male
• Middle Aged
• Vaccination