Abstract | OBJECTIVE: DESIGN: Randomized trial. SETTING: Tertiary care. SUBJECTS: INTERVENTIONS: At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine and dietary fibre (group I, n=18); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=18). Perioperatively and on postoperative day 5 the following parameters were evaluated: serum values of prealbumin, transferrin, albumin, total number of lymphocytes, interleukin 6, tumour necrosis factor alpha and c-reactive protein. RESULTS: The mean age was 59.6+/-10.9 y (two females/34 males). No significant intergroup differences in the trend of the three plasma proteins and weight were detected. CRP decreased in both groups (group I: 152.9+/-76.9 vs 68.9+/-82.5 mg/dl; P<0.05; and group II: 105.9+/-92 vs 43.6+/-59.1 mg/dl; P<0.05). Interleukin 6 did not change (group I: 16.3+/-12.3 vs 35.6+/-83.4 pg/ml; NS; and group II: 22.8+/-40 vs 9.9+/-17.7 pg/ml; NS). TNFalpha did not show any differences (group I: 4.6+/-1.6 vs 5.1+/-1.5 pg/ml; NS; and group II: 8.8+/-6.1 vs 5.8+/-1.7 pg/ml; NS). Lymphocytes increased in both groups (group I: 1405.6+/-517 vs 1634+/-529 x 10(6)/ml; P<0.05; and group II: 1355+/-696 vs 1561+/-541 x 10(6)/ml; P<0.05). CONCLUSIONS: Enhanced formula did not change IL6 and TNFalpha levels. Further studies are needed to determine whether route of nutrition or type of formula is the key in these patients.
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Authors | D A de Luis, O Izaola, L Cuellar, M C Terroba, M Arranz, N Fernandez, R Aller |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 57
Issue 1
Pg. 96-9
(Jan 2003)
ISSN: 0954-3007 [Print] England |
PMID | 12548303
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dietary Fiber
- Interleukin-6
- Tumor Necrosis Factor-alpha
- C-Reactive Protein
- Arginine
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Topics |
- Arginine
(administration & dosage, therapeutic use)
- C-Reactive Protein
(analysis)
- Dietary Fiber
(administration & dosage, therapeutic use)
- Enteral Nutrition
- Female
- Head and Neck Neoplasms
(complications, surgery, therapy)
- Humans
- Interleukin-6
(blood)
- Lymphocytes
(blood)
- Male
- Middle Aged
- Nutrition Disorders
(immunology, prevention & control)
- Postoperative Care
- Postoperative Complications
(immunology, prevention & control)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(analysis)
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