Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments.

Abstract

Thalamic deep brain stimulation (DBS) is proven to suppress tremor in Parkinson's disease (PD) and essential tremor (ET). However, there are few reports on its long-term efficacy. We studied the efficacy of DBS at 2 years and 6-7 years after electrode implantations in the ventrointermediate nucleus of the thalamus in 39 patients (20 PD, 19 ET) with severe tremor. Twenty-five of the patients completed the study. Evaluations were done in a double-blind manner with the Unified Parkinson's Disease Rating Scale (UPDRS) and Essential Tremor Rating Scale (ETRS). DBS decreased tremor sum scores in PD (P < 0.025) compared to the preoperative baseline (median, 7; Q25-75, 6-9) both at 2 years (median, 2; Q25-75, 2-3.5; n = 16) and at 6 to 7 years (median, 2.5; Q25-75, 0.5-3; n = 12). Stimulation on improved tremor sum as well as sub scores (P < 0.025) compared to stimulation off conditions. In ET, thalamic stimulation improved (P < 0.025) kinetic and positional tremor at both follow-up periods (n = 18 and n = 13, respectively) with significant improvements (P < 0.025) in hand-function tests. PD but not ET patients showed a general disease progression. Stimulation parameters were remarkably stable over time. We conclude that high-frequency electric thalamic stimulation can efficiently suppress severe tremor in PD and ET more than 6 years after permanent implantation of brain electrodes.

• Authors: Stig Rehncrona, Bo Johnels, Håkan Widner, Anna-Lena Törnqvist, Marwan Hariz, Olof Sydow
• Journal: Movement disorders : official journal of the Movement Disorder Society (Mov Disord) Vol. 18 Issue 2 Pg. 163-70 (Feb 2003) ISSN: 0885-3185 [Print] United States
• PMID: 12539209 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 Movement Disorder Society

Topics

• Aged
• Disease Progression
• Double-Blind Method
• Electric Stimulation Therapy (methods)
• Essential Tremor (epidemiology, etiology, therapy)
• Female
• Follow-Up Studies
• Humans
• Male
• Observer Variation
• Parkinson Disease (complications)
• Thalamus (physiology)
• Time