Abstract | OBJECTIVE: METHODS: The apoE phenotypes were assayed by isoelectric focusing and immunoblotting, and apolipoproteins were determined by radial immunodiffusion assay in 75 patients with AD, 36 patients with MID and 60 control subjects. RESULTS: The frequency of apo E4 allele (epsilon 4) was significantly higher and the frequency of epsilon 2 allele was lower in AD group, compared with those in the control group (0.2333 vs 0.0666, 0.0467 vs 0.0833, P < 0.05). The frequency of epsilon 4 allele in MID group was also higher than that in the control group (0.2083 vs 0.0666, P < 0.05). The fasting serum apoA 1 and E levels in AD and MID groups were remarkably lower than those in the control group (P < 0.001 and P < 0.05). CONCLUSION:
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Authors | P Fan, Y Liu, Z Zhang, B Liu, W Ge, S Ye, Y Cheng, J Chen |
Journal | Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao
(Hua Xi Yi Ke Da Xue Xue Bao)
Vol. 32
Issue 3
Pg. 389-91
(Sep 2001)
ISSN: 0257-7712 [Print] China |
PMID | 12536572
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Apolipoprotein A-I
- Apolipoproteins B
- Apolipoproteins E
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Topics |
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
(blood)
- Apolipoprotein A-I
(blood)
- Apolipoproteins B
(blood)
- Apolipoproteins E
(blood, genetics)
- Dementia, Multi-Infarct
(blood)
- Female
- Gene Frequency
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
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