[The improvement of memory retention and retrieval of a novel vasopressin fragment analog NC-1900].

Abstract

The effects of a novel vasopressin (AVP) fragment analog NC-1900 (pGlu-Asn-Ser-Pro-Arg-Gly-NH2 acetate) were studied on the performance of memory retention and retrieval in mice. NC-1900 of one time application of 1 hr after the acquired trial (electric shock) extended the latent period of passive avoidance task 21 days after the acquired trial. Though the extended response was also recognized with AVP4-9, the potency was approx. 1/1000 of NC-1900. The potentiation wasn't recognized with vasopressin. NC-1900 showed a significantly high correct answer after 21 days after the last trial in the search task. While, V1 antagonist Pmp1-Tyr (Me)2-AVP shortened the latent period of passive avoidance task. On the other hand, NC-1900 extended the reaction latency 21 days after the acquired trial by the application 1 hr before the retention trial. Though this improvement of memory retrieval was recognized with vasopressin and AVP4-9, the potency was 1/100-1/1000. NC-1900 improved the retrieval 24 h after the CO2 exposure. V1 antagonists Pmp1-Tyr-Me2-AVP or Deamino-Pen1, O-Me-Tyr2-AVP, and PMA had no effects on the retrieval 21 days after the acquired trial. These results suggest that NC-1900 may have the memory retention and retrieval potentiating action, and that phospholipase C-protein kinase C system may be involved in the former action, and the latter action not be involved.

• Authors: Tomoaki Sato, Koh-ichi Tanaka, Yoshiko Ohnishi, Toyonori Teramoto, Kenji Hirate, Takashige Nishikawa
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 120 Issue 1 Pg. 57P-60P (Nov 2002) ISSN: 0015-5691 [Print] Japan
• PMID: 12491780 (Publication Type: Journal Article)

Chemical References

• NC 1900
• Oligopeptides
• Protein Kinase C
• Type C Phospholipases
• Pyrrolidonecarboxylic Acid

Topics

• Animals
• Avoidance Learning (drug effects)
• Male
• Memory (drug effects)
• Mice
• Oligopeptides (administration & dosage, pharmacology)
• Protein Kinase C (physiology)
• Pyrrolidonecarboxylic Acid (analogs & derivatives)
• Reaction Time
• Recognition, Psychology (drug effects)
• Retention, Psychology (drug effects)
• Stimulation, Chemical
• Time Factors
• Type C Phospholipases (physiology)