Type C Phospholipases

A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLYCEROPHOSPHOLIPIDS. Although the singular term phospholipase C specifically refers to an enzyme that catalyzes the hydrolysis of PHOSPHATIDYLCHOLINE (EC 3.1.4.3), it is commonly used in the literature to refer to broad variety of enzymes that specifically catalyze the hydrolysis of PHOSPHATIDYLINOSITOLS.

Also Known As:

Networked: 1093 relevant articles (14 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jan, Chung-Ren: 21 articles (12/2014 - 03/2002)
2.	Chou, Chiang-Ting: 14 articles (12/2014 - 07/2005)
3.	Cocco, Lucio: 9 articles (01/2023 - 05/2002)
4.	Kanematsu, Takashi: 9 articles (10/2022 - 10/2011)
5.	Lo Vasco, Vincenza Rita: 9 articles (12/2020 - 07/2010)
6.	Jacobson, Kenneth A: 9 articles (05/2014 - 01/2002)
7.	Chang, Hong-Tai: 9 articles (10/2013 - 03/2002)
8.	Flores-Díaz, Marietta: 8 articles (01/2023 - 12/2003)
9.	Kuo, Chun-Chi: 8 articles (12/2014 - 01/2010)
10.	Liang, Wei-Zhe: 8 articles (12/2014 - 11/2011)

Related Diseases

1.	Infections 03/01/1992 - "However, whereas a proportion of wild-type organisms survive this early mechanism of defense to give rise to progressive infection, the phospholipase C-negative organisms are totally eliminated. " 12/15/1992 - "This study has examined the effects of vaccinia virus infection on phospholipase C activity. " 01/01/2023 - "Phospholipase C: underrated players in microbial infections." 10/01/2022 - "Molecular Characterization of Phospholipase C in Infection Structure Differentiation Induced by Pear Fruit Surface Signals, Stress Responses, Secondary Metabolism, and Virulence of Alternaria alternata." 01/01/2022 - "We found seven cellular signaling pathways, including phospholipase C signaling, Pak signaling, and nuclear factor erythroid 2p45-related factor 2 (NRF2)-mediated oxidative stress response signaling, that were inhibited by IAV infection but significantly activated by PSMA2 KD. "
2.	Necrosis 05/01/2013 - "In this study, the immunogenicity and protective efficacy of the C-terminal domain (CP251-370) of the toxin and phospholipase C (PLC; CB, 372 residues) of Clostridum bifermentans isolated from cases of clostridium necrosis were examined. " 06/01/1996 - "It produces the alpha toxin (phospholipase C), which can induce spontaneous tissue necrosis. " 10/01/2006 - "In the presence of a phospholipase C antagonist, U73122, there was significant inhibition of the S1P protective effects against apoptosis/necrosis. " 12/17/2022 - "C. ghonii secreted collagenase IV and phospholipase c and significantly promoted apoptosis and necrosis in cultured A549 cells. " 05/19/2014 - "Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages."
3.	Insulin Resistance 06/19/1993 - "Alterations of liver membrane phospholipase C activity in NIDDM, therefore, may reflect diabetic pathology other than the insulin resistance associated with this disease." 06/19/1993 - "Hepatic insulin resistance in KKA(y) mice and its amelioration by pioglitazone do not involve alterations in phospholipase C activity." 05/01/2013 - "The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes." 01/01/2021 - "Dihydromyricetin Ameliorates Inflammation-Induced Insulin Resistance via Phospholipase C-CaMKK-AMPK Signal Pathway." 11/01/2023 - "Results showed that PSP improved glucose tolerance and systemic insulin sensitivity, which coincided with decreased expression of sodium-glucose cotransporter 1 and glucose transporter 2 in the intestinal epithelium induced by an activation of the phospholipase C β2/protein kinase C signaling pathway. "
4.	Hypoxia (Hypoxemia) 01/01/2019 - "In the present study, we examined the function of phospholipase C ϵ-1 (PLCE1) by an H9c2 H/R (H/R, hypoxia-reoxygenation) model and a rat myocardial I/R injury model. " 11/01/2016 - "Surprisingly, the hypoxic upregulation of neutrophil degranulation was not dependent on hypoxia-inducible factor (HIF), nor was it fully reversed by inhibition of phospholipase C signalling. " 02/01/2013 - "We report, for the first time, that acute hypoxia significantly enhances phospholipase C (PLC) activity in mouse resistance pulmonary arteries (PAs), but not in mesenteric arteries. " 12/20/2002 - "Activation of the neuroprotective ERK signaling pathway by fructose-1,6-bisphosphate during hypoxia involves intracellular Ca2+ and phospholipase C." 11/02/2001 - "Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling."
5.	Tuberculosis (Tuberculoses) 04/09/2024 - "Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis." 12/01/2005 - "Distribution of insertion- and deletion-associated genetic polymorphisms among four Mycobacterium tuberculosis phospholipase C genes and associations with extrathoracic tuberculosis: a population-based study." 04/01/2010 - "tuberculosis H37Rv, a Beijing strain (DR-689), and two more isolates with deletion of the phospholipase C locus (plcA-plcB-plcC ), and subjected them to serial culturing on Middlebrook 7H9 medium, with or without ox bile. " 06/01/2007 - "tuberculosis strains lacking the complete phospholipase C locus produced a reduced cytotoxic effect. " 02/01/2005 - "In order to gain a better understanding of the potential role of Mycobacterium tuberculosis phospholipase C in the pathogenesis of human tuberculosis, we investigated the genetic diversity of the four M. "

Related Drugs and Biologics

1.	Protein Kinase C
2.	1- (6- ((3- methoxyestra- 1,3,5(10)- trien- 17- yl)amino)hexyl)- 1H- pyrrole- 2,5- dione
3.	Phosphatidylinositols (Phosphatidylinositol)
4.	Proteins (Proteins, Gene)
5.	Calcium
6.	Phosphotransferases (Kinase)
7.	Calmodulin (Calcium-Dependent Activator Protein)
8.	Glucose (Dextrose)
9.	Membrane Proteins (Integral Membrane Proteins)
10.	Mucins

Related Therapies and Procedures

1.	Rewarming
2.	Therapeutics
3.	Transplantation
4.	Ligation
5.	Lasers (Laser)