Abstract | INTRODUCTION: METHODS: RESULTS: Median serum homocysteine postmortem as a result of acute thrombus was 10.4 micro mol/L (P=0.4 versus controls), 12.1 micro mol/L in men with organized thrombi (P=0.1 versus controls), 15.6 micro mol/L in men without thrombus (P=0.007 versus controls), and 9.8 micro mol/L in controls. The median homocysteine was 12.1 micro mol/L in 65 men with healed infarcts (P=0.03 versus controls). The number of fibrous plaques was associated with log-normalized homocysteine (P=0.004), independent of age, albumin, smoking, hypertension, and serum cholesterol. Homocysteine levels in the upper tertile (>15 micromol/L) were associated with sudden death without acute or organized thrombus (odds ratio 3.8, P=0.03) independent of age and other risk factors; the coexistence of diabetes increased the association (odds ratio 25.1, P=0.009, versus lowest tertile < or =8.5 micromol/L). CONCLUSIONS:
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Authors | Allen P Burke, V Fonseca, Frank Kolodgie, Arthur Zieske, Louis Fink, Renu Virmani |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 22
Issue 11
Pg. 1936-41
(Nov 01 2002)
ISSN: 1524-4636 [Electronic] United States |
PMID | 12426228
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Analysis of Variance
- Coronary Artery Disease
(blood, pathology)
- Coronary Thrombosis
(blood, pathology)
- Death, Sudden, Cardiac
(epidemiology, pathology)
- Diabetes Mellitus
(blood)
- Fibrosis
- Homocysteine
(blood)
- Humans
- Male
- Middle Aged
- Multivariate Analysis
- Myocardial Infarction
(blood)
- Risk Factors
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