Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Abstract

Effects of benzyl isothiocyanate (BITC) on urinary bladder carcinogenesis were examined in rats simultaneously treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Groups of 20 6-wk-old Fischer 344 male rats were given 10, 100, or 1,000 ppm BITC in the diet or a basal diet with 50 ppm BBN in the drinking water for 40 wk and then killed for autopsy. Additional groups consisting of 10 or 9 rats were similarly given BITC or the basal diet alone without BBN treatment. With BBN treatment, dysplasia, papilloma, and carcinoma incidences and multiplicities were dramatically decreased by simultaneous treatment with BITC in a clear dose-dependent manner. In contrast, epithelial hyperplasia was induced in rats treated with 100 and 1,000 ppm BITC without BBN. These results clearly indicate that although BITC may have weak carcinogenic potency, it is a potent chemopreventive agent against bladder tumor induction by BBN.

• Authors: Kazushi Okazaki, Megumi Yamagishi, Hwa-Young Son, Takayoshi Imazawa, Fumio Furukawa, Hideaki Nakamura, Akiyoshi Nishikawa, Toshiaki Masegi, Masao Hirose
• Journal: Nutrition and cancer (Nutr Cancer) Vol. 42 Issue 2 Pg. 211-6 ( 2002) ISSN: 0163-5581 [Print] United States
• PMID: 12416262 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Isothiocyanates
• Butylhydroxybutylnitrosamine
• benzyl isothiocyanate

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Body Weight (drug effects)
• Butylhydroxybutylnitrosamine (toxicity)
• Isothiocyanates (therapeutic use)
• Male
• Organ Size (drug effects)
• Rats
• Rats, Inbred F344
• Urinary Bladder (drug effects, pathology)
• Urinary Bladder Neoplasms (chemically induced, prevention & control)