Pyridoxine (vitamin B6) toxicity: enhancement by uremia in rats.

Abstract

Pyridoxine is not completely innocuous. Large doses can cause a peripheral neuropathy despite renal excretion of this water-soluble vitamin. Renal failure patients are treated with pyridoxine to prevent a deficiency. The safety of pyridoxine treatment in the presence of renal dysfunction has not been studied. Our experiments on anephric rats show that the uremic state, in a mere 3 or 4 days, causes a 5- to 10-fold increase in susceptibility to pyridoxine-induced neuronopathy. These results suggest a need for caution in prescribing pyridoxine to uremic patients who will probably take the vitamin daily for many years.

• Authors: S Levine, A Saltzman
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 40 Issue 10 Pg. 1449-51 (Oct 2002) ISSN: 0278-6915 [Print] England
• PMID: 12387307 (Publication Type: Journal Article)

Chemical References

• Creatinine
• Pyridoxine

Topics

• Animals
• Blood Urea Nitrogen
• Creatinine (blood)
• Male
• Nervous System Diseases (chemically induced)
• Pyridoxine (administration & dosage, toxicity)
• Rats
• Rats, Inbred Lew
• Trigeminal Ganglion (pathology)
• Uremia (blood, complications, therapy)