Abstract | BACKGROUND: METHODS: FINDINGS: INTERPRETATION: Our results indicate that Cogan's syndrome is an autoimmune disease, characterised by the presence of autoantibodies able to induce tissue damage on binding of cell-surface molecules present on the sensory epithelia of the inner ear and on endothelial cells.
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Authors | Claudio Lunardi, Caterina Bason, Massimo Leandri, Riccardo Navone, Maurizio Lestani, Enrico Millo, Umberto Benatti, Michele Cilli, Ruggero Beri, Roberto Corrocher, Antonio Puccetti |
Journal | Lancet (London, England)
(Lancet)
Vol. 360
Issue 9337
Pg. 915-21
(Sep 21 2002)
ISSN: 0140-6736 [Print] England |
PMID | 12354474
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Peptide Library
- Protein Phosphatase 1
- PTPRJ protein, human
- Protein Tyrosine Phosphatases
- Ptprj protein, mouse
- Receptor-Like Protein Tyrosine Phosphatases, Class 3
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Topics |
- Animals
- Autoantibodies
(classification, isolation & purification)
- Autoimmune Diseases
(genetics, immunology)
- Case-Control Studies
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Female
- Hearing Loss, Sensorineural
(genetics, immunology)
- Humans
- Mice
- Mice, Inbred C57BL
- Molecular Mimicry
- Peptide Library
- Protein Phosphatase 1
- Protein Tyrosine Phosphatases
(immunology)
- Receptor-Like Protein Tyrosine Phosphatases, Class 3
- Syndrome
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