Effect of tonsillectomy on serum concentrations of interleukins and TNF-alpha in patients with chronic tonsillitis.

Abstract

We investigated serum interleukin (IL)-1beta, IL-4, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha levels in 17 children aged 5-12 years (mean 7) with chronic tonsillitis before and after tonsillectomy. Cytokine concentrations were measured by enzyme-linked immunosorbent assay. IL-1beta and IL-6 levels were significantly higher than the control levels (p < 0.05) in preoperative serum samples. Other cytokine levels were within normal limits. After tonsillectomy, IL-1beta and IL-6 levels were significantly reduced (p < 0.05). It is suggested that IL-1beta and IL-6 may be mediators which have a role in chronic tonsillitis disease and that tonsillectomy has a significant effect on preoperative IL-1beta and IL-6 serum levels.

• Authors: Murat Unal, Candan Oztürk, Kemal Görür
• Journal: ORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) 2002 Jul-Aug Vol. 64 Issue 4 Pg. 254-6 ISSN: 0301-1569 [Print] Switzerland
• PMID: 12232470 (Publication Type: Journal Article)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Interleukins
• Tumor Necrosis Factor-alpha

Topics

• Child
• Child, Preschool
• Chronic Disease
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Interleukins (blood)
• Male
• Statistics, Nonparametric
• Tonsillectomy
• Tonsillitis (blood, surgery)
• Tumor Necrosis Factor-alpha (metabolism)