[Level of serum tumor necrosis factor-alpha and the degree of liver fibrosis in children with chronic viral hepatitis B, C and B+C, treated with interferon-alpha].

Abstract

Children with chronic virus hepatitis B and C, as well as combined chronic virus hepatitis B + C, were found to have a higher level of tumor necrosis factor-alpha (TNF-alpha) in their serum than healthy children. Complete clinical and virological response to treatment with interferon-alpha is accompanied by a decreased inflammation and fibrosis of the liver, as well as by a decreased level of TNF-alpha, in comparison with nonresponsive patients. Positive correlation between the level of TNF-alpha and the degree of liver fibrosis in sick children was noted.

• Authors: P N Filimonov, T G Sukhenko, N I Gavrilova
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2002 Mar-Apr Issue 2 Pg. 69-72 ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Uroven' faktora nekroza opukholi-alfa v syvorotke i stepen' fibroza pecheni u deteĭ s khronicheskim virusnym gepatitom B, C i B+C pri lechenii interferonom-alfa.
• PMID: 12043158 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Biomarkers
• Interferon Type I
• Recombinant Proteins
• Tumor Necrosis Factor-alpha

Topics

• Adolescent
• Antiviral Agents (therapeutic use)
• Biomarkers
• Child
• Child, Preschool
• Cohort Studies
• Fibrosis
• Hepatitis B, Chronic (blood, complications, drug therapy, pathology)
• Hepatitis C, Chronic (blood, complications, drug therapy, pathology)
• Humans
• Interferon Type I (therapeutic use)
• Liver Cirrhosis (blood, complications, pathology, virology)
• Recombinant Proteins
• Tumor Necrosis Factor-alpha (analysis)