Abstract | BACKGROUND AND AIM: METHODS: RESULTS: Final group sizes were: AM=15, PM=16, AP=16 and PP=15. PD improved in all groups. Treatment effects were highly significantly different and always greatest in the AM and least in the PP groups. Benefits of PM and AP over PP were also noted. LOA improved in all groups and showed the same highly significant treatment differences, again favouring AM. BOP improved in all groups, particularly in AM compared to the other groups. SUPP improved in all groups and was virtually eradicated in AM with differences among treatments highly significant. DEP changed little in any group and there were no significant differences among groups. Microbiological data showed significant differences in favour of AM compared to PP and PM for total aerobes and anaerobes at 1 month. P. intermedia counts were always lower in active groups compared to PP and reached significance for AM and AP at 1 month and AM and PM at 3 months. CONCLUSION: The significant differences among treatment groups and the overall trend in the data, in line with other studies, support the considerable adjunctive benefits to SRP of amoxycillin and metronidazole combined in the treatment of advanced chronic periodontal disease.
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Authors | J Rooney, W G Wade, S V Sprague, R G Newcombe, M Addy |
Journal | Journal of clinical periodontology
(J Clin Periodontol)
Vol. 29
Issue 4
Pg. 342-50
(Apr 2002)
ISSN: 0303-6979 [Print] United States |
PMID | 11966932
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Bacterial Agents
- Capsules
- Drug Combinations
- Penicillins
- Placebos
- Tablets
- Metronidazole
- Amoxicillin
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Topics |
- Adult
- Amoxicillin
(administration & dosage, therapeutic use)
- Analysis of Variance
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Capsules
- Chronic Disease
- Colony Count, Microbial
- Combined Modality Therapy
- Dental Plaque
(classification, microbiology)
- Dental Scaling
- Double-Blind Method
- Drug Combinations
- Follow-Up Studies
- Gingival Hemorrhage
(drug therapy, therapy)
- Humans
- Linear Models
- Metronidazole
(administration & dosage, therapeutic use)
- Middle Aged
- Penicillins
(administration & dosage, therapeutic use)
- Periodontal Attachment Loss
(drug therapy, therapy)
- Periodontal Diseases
(drug therapy, therapy)
- Periodontal Pocket
(drug therapy, therapy)
- Placebos
- Prevotella intermedia
(drug effects, growth & development)
- Root Planing
- Suppuration
- Tablets
- Treatment Outcome
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