Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma.

Abstract

BACKGROUND:

PTEN is a candidate tumor-suppressor gene in a variety of malignant tumors. The prognostic importance of PTEN product protein (PTEN) and its correlation with clinicopathologic characteristics have yet to be delineated in patients with esophageal carcinoma.

METHODS:

Specimens from 97 patients with esophageal squamous cell carcinoma were used for the immunohistochemical evaluation of PTEN expression.

RESULTS:

PTEN expression was detected in the nucleus in 48 specimens (49.5%). There were statistically significant correlations between nuclear PTEN expression and macroscopic tumor classification, T stage, and American Joint Committee on Cancer (AJCC) stage (P < 0.01), indicating that PTEN expression was down-regulated by advancement of the disease process. There were no statistically significant correlations between nuclear PTEN expression and the intensity and extent of cytoplasmic PTEN expression. The 10-year overall survival rate was significantly better in patients with positive nuclear PTEN expression (n = 48 patients) compared with the rate in patients with negative nuclear PTEN expression (n = 49 patients; P < 0.01). The results of a multivariate analysis of factors that were prognostic for survival showed that AJCC stage (P < 0.05; relative risk, 2.038) and negative nuclear PTEN expression (P < 0.05; relative risk, 1.825) were significant factors indicative of poor survival.

CONCLUSIONS:

Nuclear PTEN expression may be a favorable biologic marker and a useful prognostic indicator in patients with esophageal squamous cell carcinoma.

• Authors: Mitsuo Tachibana, Muneaki Shibakita, Satoshi Ohno, Shoichi Kinugasa, Hiroshi Yoshimura, Shuhei Ueda, Toshiyuki Fujii, Mohammad A Rahman, Dipok K Dhar, Naofumi Nagasue
• Journal: Cancer (Cancer) Vol. 94 Issue 7 Pg. 1955-60 (Apr 01 2002) ISSN: 0008-543X [Print] United States
• PMID: 11932897 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 American Cancer Society.

Chemical References

• Biomarkers, Tumor
• Tumor Suppressor Proteins
• Phosphoric Monoester Hydrolases
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, pathology)
• Cell Nucleus (metabolism)
• Cytoplasm (metabolism)
• Esophageal Neoplasms (metabolism, mortality, pathology)
• Female
• Genes, Tumor Suppressor
• Germ-Line Mutation
• Humans
• Immunoenzyme Techniques
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• PTEN Phosphohydrolase
• Phosphoric Monoester Hydrolases (metabolism)
• Prognosis
• Survival Rate
• Tumor Suppressor Proteins (metabolism)