Abstract | BACKGROUND AND OBJECTIVES: Oxidative stress secondary to infant tonsillar infection produces the expression of local and systemic antioxidants. Its determination seems to be useful as a marker of tonsillar suffering before tonsillectomy but is currently unknown. The aim of this study was to determine the evolution of this parameter in tonsillectomized children during a long-term follow-up. METHODS: RESULTS:
Infection provoked significantly higher SOD concentrations than tonsillar hypertrophy in tonsillar tissue (223.06 30.46 vs 156.39 54.05 U/l, p < 0.001) and in blood (1124.91 141.73 vs 1007.19 97.03 U/gr Hb, p < 0.001). There was a strong correlation between tonsillar and erythrocyte concentrations. During the 3-year follow-up, SOD concentrations in blood progressively decreased until stabilizing in all patients. Stabilization was reached at 6 months post- tonsillectomy in the group with tonsillar hypertrophy and at 2 years in the group with infection. Children with recurrent tonsillitis consistently showed higher SOD concentrations in blood throughout the follow-up. CONCLUSIONS: Oxidative damage in tonsillar tissue results from the incidence and severity of focal infections. Tonsillectomy reduces SOD levels but, as a consequence of oxidative stress, these do not return to normal.
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Authors | F J García Callejo, M H Orts Alborch, A Morant Ventura, I Costa Alcácer, M M Velert Vila, L Blay Galaud |
Journal | Anales espanoles de pediatria
(An Esp Pediatr)
Vol. 56
Issue 4
Pg. 310-7
(Apr 2002)
ISSN: 0302-4342 [Print] Spain |
Vernacular Title | Niveles de superóxido dismutasa amigdalar y eritrocitaria en niños con y sin amigdalitis de repetición. |
PMID | 11927098
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Age Factors
- Child
- Child, Preschool
- Erythrocytes
(enzymology)
- Follow-Up Studies
- Humans
- Oxidative Stress
- Palatine Tonsil
(enzymology)
- Recurrence
- Spectrophotometry
- Superoxide Dismutase
(analysis, blood)
- Time Factors
- Tonsillectomy
- Tonsillitis
(enzymology, surgery)
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