[Acute coronary syndrome--better risk stratification by determination of inflammatory parameters?].

Abstract

BACKGROUND:

In the past years coronary atherosclerosis and plaque rupture have been characterized not only as a problem of growth of smooth vascular cells, of activated thrombocytes and coagulation but also of inflammation.

PARAMETERS OF INFLAMMATION:

Several studies have demonstrated the importance of C-reactive protein as a marker for cardiovascular complications. Also interleukin-6, tumor necrosis factor-alpha and adhesion molecules are discussed as predictors of a poor prognosis in patients with acute coronary syndromes.

RISK STRATIFICATION:

A positive troponin T test is correlated with an increased rate of early complications; thus, these patients benefit from an aggressive therapy with GP IIb/IIIa receptor antagonists and acute coronary intervention. The C-reactive protein is predictive for late complications such as restenosis, reinfarction and death due to cardiac events; these patients benefit from close controls and from an anti-inflammatory therapy with acetylsalicyclic acid and statins.

• Authors: Andreas Link, Michael Böhm, Georg Nickenig
• Journal: Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 97 Issue 2 Pg. 63-9 (Feb 15 2002) ISSN: 0723-5003 [Print] Germany
• Vernacular Title: Akutes Koronarsyndrom--bessere Risikostratifizierung durch Bestimmung von Entzündungsparametern?
• PMID: 11910871 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Cell Adhesion Molecules
• Inflammation Mediators
• Interleukin-6
• Tumor Necrosis Factor-alpha
• C-Reactive Protein

Topics

• C-Reactive Protein (metabolism)
• Cell Adhesion Molecules (blood)
• Coronary Artery Disease (diagnosis, immunology)
• Humans
• Inflammation Mediators (blood)
• Interleukin-6 (blood)
• Myocardial Infarction (diagnosis, immunology)
• Prognosis
• Tumor Necrosis Factor-alpha (metabolism)