Abstract | BACKGROUND AND AIMS: METHODS: Serum and saliva from 12 patients with PBC were tested for AMA by immunoblotting on bovine heart mitochondria, and by an automated microassay based on inhibition of the enzymatic activity of PDC. RESULTS: CONCLUSIONS: The presence of AMA in saliva to 2-OAD enzymes indicates that salivary glands could participate in the pathogenetic process of PBC. The detection of salivary AMA by a semi-automated enzyme inhibition assay offers possibilities for rapid population screening for detection of preclinical PBC among at-risk individuals, middle-aged to older women.
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Authors | N Ikuno, I R Mackay, J Jois, K Omagari, M J Rowley |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 16
Issue 12
Pg. 1390-4
(Dec 2001)
ISSN: 0815-9319 [Print] Australia |
PMID | 11851838
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
- Pyruvate Dehydrogenase Complex
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Topics |
- Adult
- Antibody Specificity
- Autoantibodies
(blood, immunology)
- Female
- Hepatitis, Autoimmune
(immunology)
- Humans
- Immunoenzyme Techniques
(methods)
- Immunoglobulin A
(analysis)
- Immunoglobulin G
(analysis)
- Immunoglobulin M
(analysis)
- Liver Cirrhosis, Biliary
(immunology)
- Male
- Middle Aged
- Mitochondria
(immunology)
- Mouth Mucosa
(immunology)
- Pyruvate Dehydrogenase Complex
(immunology)
- Saliva
(immunology)
- Sjogren's Syndrome
(immunology)
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