Hypothermic action of exogenously administered melatonin is dose-dependent in humans.

Abstract

The pineal hormone melatonin (MLT) is closely related to sleep initiation and maintenance in humans, and is now used as a potent therapeutic tool for some circadian rhythm sleep disorders. Acute and transient hypothermia induced by exogenously administered MLT (ex-MLT) may play a critical role in the circadian phase shifting and hypnogenic actions. Six healthy young male volunteers (mean age, 22.5 y; age range, 19-24 y), whose endogenous MLT secretion rhythms were previously assessed, took either 0.5 mg, 3 mg, or 9 mg of ex-MLT or a placebo at 0930 h (the average sleep onset time was 0000 h) on a randomized, single-blind, crossover basis. In comparison with placebo, ex-MLT significantly suppressed core body temperature at the 3-mg and 9-mg doses and slightly suppressed core body temperature at the 0.5-mg dose. There was significant positive correlation between the magnitude of core body temperature suppression and the area under the MLT concentration curve as well as the peak MLT concentration after ex-MLT administration. Our study showed that clinical doses of ex-MLT induce hypothermia in a dose-dependent manner. Results suggest that the therapeutic effect of larger doses of ex-MLT should be tested on patients who benefit little from typically lower clinical doses of ex-MLT.

• Authors: K Satoh, K Mishima
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2001 Nov-Dec Vol. 24 Issue 6 Pg. 334-40 ISSN: 0362-5664 [Print] United States
• PMID: 11801808 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Melatonin

Topics

• Adult
• Body Temperature (drug effects)
• Depression, Chemical
• Dose-Response Relationship, Drug
• Humans
• Male
• Melatonin (administration & dosage, pharmacokinetics, pharmacology)
• Polysomnography
• Sleep (drug effects)