The glycine allele of a glycine/arginine polymorphism in the beta2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin.

Abstract

BACKGROUND:

Several studies implicate polymorphisms in the human beta-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area.

METHODS:

We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5' leader cistron; another C/T transition that results in a glycine/ arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln).

RESULTS:

The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population.

CONCLUSIONS:

The Glyl6 allele in the beta2-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin.

• Authors: K Ranade, W H Shue, Y J Hung, C A Hsuing, F T Chiang, R Pesich, J Hebert, M Olivier, Y D Chen, R Pratt, R Olshen, D Curb, D Botstein, N Risch, D R Cox
• Journal: American journal of hypertension (Am J Hypertens) Vol. 14 Issue 12 Pg. 1196-200 (Dec 2001) ISSN: 0895-7061 [Print] United States
• PMID: 11775126 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Adrenergic, beta-2
• Arginine
• Glycine

Topics

• Arginine (genetics)
• Asian People (genetics)
• Blood Pressure (genetics)
• Family Health
• Female
• Genotype
• Glycine (genetics)
• Humans
• Hypertension (ethnology, genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Receptors, Adrenergic, beta-2 (genetics)