Increased p50/p50 NF-kappaB activation in human papillomavirus type 6- or type 11-induced laryngeal papilloma tissue.

Abstract

We have observed elevated NF-kappaB DNA-binding activity in nuclear extracts from human papillomavirus type 6- and 11-infected laryngeal papilloma tissues. The predominant DNA-binding species is the p50/p50 homodimer. The elevated NF-kappaB activity could be correlated with a reduced level of cytoplasmic IkappaBbeta and could be associated with the overexpression of p21(CIP1/WAF1) in papilloma cells. Increased NF-kappaB activity and cytoplasmic accumulation of p21(CIP1/WAF1) might counteract death-promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues.

• Authors: Ivana Vancurova, Rong Wu, Veronika Miskolci, Shishinn Sun
• Journal: Journal of virology (J Virol) Vol. 76 Issue 3 Pg. 1533-6 (Feb 2002) ISSN: 0022-538X [Print] United States
• PMID: 11773428 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• CDKN1A protein, human
• Cell Extracts
• Cyclin-Dependent Kinase Inhibitor p21
• Cyclins
• DNA-Binding Proteins
• I kappa B beta protein
• I-kappa B Proteins
• NF-kappa B
• NF-kappa B p50 Subunit
• Transcription Factor RelA
• DNA

Topics

• Cell Extracts
• Cell Nucleus (metabolism)
• Cyclin-Dependent Kinase Inhibitor p21
• Cyclins (metabolism)
• DNA (metabolism)
• DNA-Binding Proteins (metabolism)
• Dimerization
• Humans
• I-kappa B Proteins
• Laryngeal Neoplasms (metabolism, pathology)
• NF-kappa B (genetics, metabolism)
• NF-kappa B p50 Subunit
• Papilloma (metabolism, pathology)
• Papillomaviridae (physiology)
• Papillomavirus Infections (metabolism, pathology)
• Transcription Factor RelA
• Tumor Virus Infections (metabolism, pathology)