[Pharmacologic effects in combined use of oxyfedrine and beta-acetyldiogoxin].

Abstract

In guinea pigs the toxic effect of beta-acetyldigoxin was not increased by simultaneously administered 3-(beta-hydroxy-alpha-methyl-phenethyl-amino)-3'-methoxy-propiophenone (oxy-fedrine). There was no evidence of a potentiation of the glycoside effect by the combination with oxyfedrine (ildamen-Novodigal). The threshold dose for arrhythmia was increased: typical glycoside tachyarrhythmias only occurred after higher infused doses. In anesthetized dogs with heart failure by overdosed pentobarbital, the therapeutic effects of beta-acetyldigoxin were sustained and enhanced by oxyfedrine.

• Authors: V F Stroman, R Hempel
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 25 Issue 3 Pg. 386-8 (Mar 1975) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Uber pharmakologische Wirkungen bei der kombinierten Anwendung von Oxyfedrin mit beta-Acetyldigoxin
• PMID: 1174037 (Publication Type: English Abstract, Journal Article)

Chemical References

• Propiophenones
• Digoxin
• Oxyfedrine

Topics

• Animals
• Blood Pressure (drug effects)
• Cats
• Central Venous Pressure (drug effects)
• Coronary Circulation (drug effects)
• Digoxin (analogs & derivatives, pharmacology, toxicity)
• Dogs
• Drug Interactions
• Guinea Pigs
• Heart Rate (drug effects)
• Heart Ventricles (drug effects)
• Hemodynamics (drug effects)
• Male
• Myocardial Contraction (drug effects)
• Oxyfedrine (pharmacology, toxicity)
• Papillary Muscles (drug effects)
• Propiophenones (pharmacology)
• Vascular Resistance (drug effects)