Abstract | BACKGROUND: METHODS: Hearts of F344 rats were heterotopically transplanted into Lewis rat recipients immunosuppressed with cyclosporine (10 mg/kg/day). Recipients were treated orally with the AT(1) receptor blocker L-158809 (3 mg/kg/day, n = 6), enalapril (3 mg/kg/day, n = 6), or vehicle only (n = 6) for 90 days. Density of myocordial beta-ARs was determined with an autoradiographic technique using [(3)H] CGP-12177. RESULTS: Graft status, the sum of the functional score and the score for color, was preserved better in the L-158809-treated group (5.8 +/- 0.9) and in the enalapril-treated group (5.6 +/- 0.8) than in the vehicle-treated group (3.8 +/- 0.9, p < 0.05). The grades of graft coronary artery disease in the L-158809-treated group and in the enalapril-treated group were significantly less than that seen in the vehicle-treated group. The density of myocardial beta-AR (fmol/mg of protein) was 3.5 +/- 0.5 in the L-158809-treated group (p < 0.05 vs. vehicle-treated group) and 3.2 +/- 0.5 (p < 0.05) in the enalapril-treated group but was 2.2 +/- 0.4 in the vehicle-treated group. CONCLUSION:
L-158809 is as effective as enalapril in restoring myocardial beta-AR density in immunosuppressed rat transplant model, and this efficacy, as well as the prevention of graft coronary arteriosclerosis, is probably associated with the preservation of graft status.
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Authors | T Nakame, A Iguchi, K Tabayashi |
Journal | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
(Eur Surg Res)
2001 Jul-Aug
Vol. 33
Issue 4
Pg. 297-302
ISSN: 0014-312X [Print] Switzerland |
PMID | 11684837
(Publication Type: Journal Article)
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Copyright | Copyright 2001 S. Karger AG, Basel |
Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Imidazoles
- Receptor, Angiotensin, Type 1
- Receptors, Adrenergic, beta
- Tetrazoles
- L 158809
- Enalapril
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Topics |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Enalapril
(pharmacology)
- Heart
(drug effects)
- Heart Transplantation
- Imidazoles
(pharmacology)
- Male
- Rats
- Rats, Inbred F344
- Rats, Inbred Lew
- Receptor, Angiotensin, Type 1
- Receptors, Adrenergic, beta
(analysis, drug effects)
- Tetrazoles
(pharmacology)
- Transplantation, Heterotopic
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