Abstract |
Interleukin (IL)-1alpha, IL-1beta, and IL-1ra contribute to regulation of the inflammatory response in periodontal tissues. We aimed to investigate the distribution of polymorphisms in the IL-1 gene family among periodontitis patients and controls, taking into account smoking and microbiology as additional variables. Fifty-three non-smoking and 52 smoking patients with severe adult periodontitis and 53 controls were genotyped for bi-allelic IL-1A(-889), IL-1B(-3954), and a penta-allelic 86-bp VNTR IL-1RN gene polymorphisms. The presence of Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans was established by culture techniques. We found a higher frequency of allele 2 carriage in IL-1A, IL-1B, and IL-1RN in periodontitis patients who were non-smokers and in whom P. gingivalis and A. actinomycetemcomitans could not be detected (42.1% vs. 11.3% in controls; P = 0.0068; OR 5.7, 95% CI: 1.6-19.8). Our results provide evidence that polymorphisms in genes of the IL-1 family are associated with severe adult periodontitis in the absence of other risk factors tested in this patient population.
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Authors | M L Laine, M A Farré, G González, L J van Dijk, A J Ham, E G Winkel, J B Crusius, J P Vandenbroucke, A J van Winkelhoff, A S Peña |
Journal | Journal of dental research
(J Dent Res)
Vol. 80
Issue 8
Pg. 1695-9
(Aug 2001)
ISSN: 0022-0345 [Print] United States |
PMID | 11669477
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aggregatibacter actinomycetemcomitans
(physiology)
- Humans
- Interleukin-1
(genetics)
- Periodontitis
(immunology, microbiology, physiopathology)
- Polymorphism, Genetic
(genetics)
- Porphyromonas gingivalis
(physiology)
- Smoking
(physiopathology)
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