Drug-induced hypersensitivity syndrome in pediatric patients.

Abstract

The antiepileptic hypersensitivity syndrome is a severe, multiorgan reaction to oral antiepileptics that manifests as fever, rash, lymphadenopathy, and hepatitis. This same reaction pattern also has been described following administration of a few unrelated medications. We report on 11 patients who had drug-induced hypersensitivity syndrome and were admitted to our pediatric service and review 94 cases of this syndrome in pediatric patients identified from the literature. We undertook this study to summarize the findings and alert clinicians to the severe internal organ involvement that can occur with this syndrome.

• Authors: M C Carroll, K A Yueng-Yue, N B Esterly, B A Drolet
• Journal: Pediatrics (Pediatrics) Vol. 108 Issue 2 Pg. 485-92 (Aug 2001) ISSN: 1098-4275 [Electronic] United States
• PMID: 11483822 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants

Topics

• Adolescent
• Age Factors
• Anticonvulsants (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Diagnosis, Differential
• Drug Eruptions (diagnosis, etiology, pathology)
• Drug Hypersensitivity (diagnosis, etiology, pathology)
• Drug-Related Side Effects and Adverse Reactions
• Female
• Humans
• Infant
• Male
• Mucous Membrane (pathology)
• Pediatrics
• Skin (pathology)
• Syndrome