Abstract | PURPOSE: METHODS: RESULTS: There was no significant difference in maximal level of sensory block among the three groups. The morphine group had a later onset of postsurgical pain and longer time to first rescue analgesics than the neostigmine group (P <0.05). Overall 24-hr VAS pain scores were significantly higher in the saline group vs the morphine and neostigmine groups (P <0.05). Motor block lasted significantly longer in the neostigmine group than in the morphine and saline groups (P <0.05). The incidence of adverse effects was similar in the neostigmine and morphine groups except for pruritus (70%) occurring more frequently in the morphine group than in the neostigmine and saline groups (0%; P <0.05). Overall satisfaction rates were better in the neostigmine group than in the morphine and saline groups (P <0.05). CONCLUSIONS: IT neostigmine 50 microg produced postoperative analgesia lasting about seven hours with fewer side effects and better satisfaction ratings than IT morphine 300 microg.
|
Authors | P H Tan, Y Y Chia, Y Lo, K Liu, L C Yang, T H Lee |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 48
Issue 6
Pg. 551-6
(Jun 2001)
ISSN: 0832-610X [Print] United States |
PMID | 11444449
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Analgesics, Opioid
- Anesthetics, Local
- Parasympathomimetics
- Neostigmine
- Morphine
- Bupivacaine
|
Topics |
- Aged
- Analgesics, Opioid
(administration & dosage, therapeutic use)
- Anesthetics, Local
(administration & dosage, therapeutic use)
- Arthroplasty, Replacement, Knee
- Bupivacaine
(administration & dosage, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Injections, Spinal
- Male
- Middle Aged
- Morphine
(administration & dosage, therapeutic use)
- Neostigmine
(administration & dosage, therapeutic use)
- Pain, Postoperative
(drug therapy)
- Parasympathomimetics
(administration & dosage, therapeutic use)
|