Allogeneic transplantation of blood stem cells: coming of age?

Abstract

Mobilized peripheral blood progenitor cells (PBSC) are increasingly being used instead of bone marrow for allogeneic transplantation. The purpose of the present article is to give a concise and clinically oriented overview on current results and perspectives of allogeneic peripheral blood stem cell transplantation, with particular focus on reconstitution of hematopoiesis and the immune system, graft-versus-host disease, graft-versus-leukemia effects, intensity-reduced conditioning, and graft engineering.

• Authors: P Dreger, N Schmitz
• Journal: Annals of hematology (Ann Hematol) Vol. 80 Issue 3 Pg. 127-36 (Mar 2001) ISSN: 0939-5555 [Print] Germany
• PMID: 11320896 (Publication Type: Journal Article, Review)

Topics

• Graft vs Host Disease
• Graft vs Leukemia Effect
• Hematopoiesis
• Hematopoietic Stem Cell Transplantation
• Humans
• Leukemia (therapy)
• T-Lymphocytes
• Transplantation Conditioning
• Transplantation, Homologous