Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report.

Abstract

A case of successful combination chemotherapy using vincristine, procarbazine, VP-16 and prednisolone to treat an inoperable low grade astrocytoma is presented. This patient, whose tumor was also resistant to radiotherapy, had well controlled symptoms after the initiation of chemotherapy. A brain CT scan demonstrated disappearance of the tumor mass after eight courses of a combination chemotherapy regimen. She is at present symptom-free 80 months after diagnosis. This result suggests that combination chemotherapy may offer treatment modalities for low grade astrocytoma.

• Authors: P Maipang MVasiknanonte, S Janjindamai SHirunpat
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 83 Issue 12 Pg. 1525-9 (Dec 2000) ISSN: 0125-2208 [Print] Thailand
• PMID: 11253894 (Publication Type: Case Reports, Journal Article)

Chemical References

• Procarbazine
• Vincristine
• Etoposide
• Prednisolone

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Astrocytoma (drug therapy, radiotherapy)
• Brain Neoplasms (drug therapy, radiotherapy)
• Child
• Etoposide (administration & dosage)
• Female
• Humans
• Prednisolone (administration & dosage)
• Procarbazine (administration & dosage)
• Vincristine (administration & dosage)